A human in vitro model system for investigating genome-wide host responses to SARS coronavirus infection.
Identifieur interne : 005493 ( Main/Exploration ); précédent : 005492; suivant : 005494A human in vitro model system for investigating genome-wide host responses to SARS coronavirus infection.
Auteurs : Lisa F P. Ng [Singapour] ; Martin L. Hibberd ; Eng-Eong Ooi ; Kin-Fai Tang ; Soek-Ying Neo ; Jenny Tan ; Karuturi R Krishna Murthy ; Vinsensius B. Vega ; Jer-Ming Chia ; Edison T. Liu ; Ee-Chee RenSource :
- BMC infectious diseases [ 1471-2334 ] ; 2004.
Descripteurs français
- KwdFr :
- ARN viral (génétique), ARN viral (isolement et purification), Agranulocytes (virologie), Animaux, Cellules Vero, Cinétique, Humains, Réaction de polymérisation en chaîne, Régulation de l'expression des gènes viraux, Réplication virale (physiologie), Syndrome respiratoire aigu sévère (immunologie), Syndrome respiratoire aigu sévère (virologie), Séquençage par oligonucléotides en batterie, Virus du SRAS (génétique), Virus du SRAS (immunologie), Virus du SRAS (physiologie).
- MESH :
- génétique : ARN viral, Virus du SRAS.
- immunologie : Syndrome respiratoire aigu sévère, Virus du SRAS.
- isolement et purification : ARN viral.
- physiologie : Réplication virale, Virus du SRAS.
- virologie : Agranulocytes, Syndrome respiratoire aigu sévère.
- Animaux, Cellules Vero, Cinétique, Humains, Réaction de polymérisation en chaîne, Régulation de l'expression des gènes viraux, Séquençage par oligonucléotides en batterie.
English descriptors
- KwdEn :
- Animals, Chlorocebus aethiops, Gene Expression Regulation, Viral, Humans, Kinetics, Leukocytes, Mononuclear (virology), Oligonucleotide Array Sequence Analysis, Polymerase Chain Reaction, RNA, Viral (genetics), RNA, Viral (isolation & purification), SARS Virus (genetics), SARS Virus (immunology), SARS Virus (physiology), Severe Acute Respiratory Syndrome (immunology), Severe Acute Respiratory Syndrome (virology), Vero Cells, Virus Replication (physiology).
- MESH :
- chemical , genetics : RNA, Viral.
- chemical , isolation & purification : RNA, Viral.
- genetics : SARS Virus.
- immunology : SARS Virus, Severe Acute Respiratory Syndrome.
- physiology : SARS Virus, Virus Replication.
- virology : Leukocytes, Mononuclear, Severe Acute Respiratory Syndrome.
- Animals, Chlorocebus aethiops, Gene Expression Regulation, Viral, Humans, Kinetics, Oligonucleotide Array Sequence Analysis, Polymerase Chain Reaction, Vero Cells.
Abstract
The molecular basis of severe acute respiratory syndrome (SARS) coronavirus (CoV) induced pathology is still largely unclear. Many SARS patients suffer respiratory distress brought on by interstitial infiltration and frequently show peripheral blood lymphopenia and occasional leucopenia. One possible cause of this could be interstitial inflammation, following a localized host response. In this study, we therefore examine the immune response of SARS-CoV in human peripheral blood mononuclear cells (PBMCs) over the first 24 hours.
DOI: 10.1186/1471-2334-4-34
PubMed: 15357874
Affiliations:
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Le document en format XML
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Ng</name><affiliation wicri:level="1"><nlm:affiliation>Genome Institute of Singapore, 60 Biopolis Street, Genome, #02-01, Singapore 138672. ngfp@gis.a-star.edu.sg</nlm:affiliation><country wicri:rule="url">Singapour</country></affiliation></author><author><name sortKey="Hibberd, Martin L" sort="Hibberd, Martin L" uniqKey="Hibberd M" first="Martin L" last="Hibberd">Martin L. Hibberd</name></author><author><name sortKey="Ooi, Eng Eong" sort="Ooi, Eng Eong" uniqKey="Ooi E" first="Eng-Eong" last="Ooi">Eng-Eong Ooi</name></author><author><name sortKey="Tang, Kin Fai" sort="Tang, Kin Fai" uniqKey="Tang K" first="Kin-Fai" last="Tang">Kin-Fai Tang</name></author><author><name sortKey="Neo, Soek Ying" sort="Neo, Soek Ying" uniqKey="Neo S" first="Soek-Ying" last="Neo">Soek-Ying Neo</name></author><author><name sortKey="Tan, Jenny" sort="Tan, Jenny" uniqKey="Tan J" first="Jenny" last="Tan">Jenny Tan</name></author><author><name sortKey="Murthy, Karuturi R Krishna" sort="Murthy, Karuturi R Krishna" uniqKey="Murthy K" first="Karuturi R Krishna" last="Murthy">Karuturi R Krishna Murthy</name></author><author><name sortKey="Vega, Vinsensius B" sort="Vega, Vinsensius B" uniqKey="Vega V" first="Vinsensius B" last="Vega">Vinsensius B. Vega</name></author><author><name sortKey="Chia, Jer Ming" sort="Chia, Jer Ming" uniqKey="Chia J" first="Jer-Ming" last="Chia">Jer-Ming Chia</name></author><author><name sortKey="Liu, Edison T" sort="Liu, Edison T" uniqKey="Liu E" first="Edison T" last="Liu">Edison T. Liu</name></author><author><name sortKey="Ren, Ee Chee" sort="Ren, Ee Chee" uniqKey="Ren E" first="Ee-Chee" last="Ren">Ee-Chee Ren</name></author></analytic><series><title level="j">BMC infectious diseases</title><idno type="eISSN">1471-2334</idno><imprint><date when="2004" type="published">2004</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Chlorocebus aethiops</term><term>Gene Expression Regulation, Viral</term><term>Humans</term><term>Kinetics</term><term>Leukocytes, Mononuclear (virology)</term><term>Oligonucleotide Array Sequence Analysis</term><term>Polymerase Chain Reaction</term><term>RNA, Viral (genetics)</term><term>RNA, Viral (isolation & purification)</term><term>SARS Virus (genetics)</term><term>SARS Virus (immunology)</term><term>SARS Virus (physiology)</term><term>Severe Acute Respiratory Syndrome (immunology)</term><term>Severe Acute Respiratory Syndrome (virology)</term><term>Vero Cells</term><term>Virus Replication (physiology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>ARN viral (génétique)</term><term>ARN viral (isolement et purification)</term><term>Agranulocytes (virologie)</term><term>Animaux</term><term>Cellules Vero</term><term>Cinétique</term><term>Humains</term><term>Réaction de polymérisation en chaîne</term><term>Régulation de l'expression des gènes viraux</term><term>Réplication virale (physiologie)</term><term>Syndrome respiratoire aigu sévère (immunologie)</term><term>Syndrome respiratoire aigu sévère (virologie)</term><term>Séquençage par oligonucléotides en batterie</term><term>Virus du SRAS (génétique)</term><term>Virus du SRAS (immunologie)</term><term>Virus du SRAS (physiologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>RNA, Viral</term></keywords><keywords scheme="MESH" type="chemical" qualifier="isolation & purification" xml:lang="en"><term>RNA, Viral</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>SARS Virus</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>ARN viral</term><term>Virus du SRAS</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Syndrome respiratoire aigu sévère</term><term>Virus du SRAS</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>SARS Virus</term><term>Severe Acute Respiratory Syndrome</term></keywords><keywords scheme="MESH" qualifier="isolement et purification" xml:lang="fr"><term>ARN viral</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Réplication virale</term><term>Virus du SRAS</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>SARS Virus</term><term>Virus Replication</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Agranulocytes</term><term>Syndrome respiratoire aigu sévère</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Leukocytes, Mononuclear</term><term>Severe Acute Respiratory Syndrome</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Chlorocebus aethiops</term><term>Gene Expression Regulation, Viral</term><term>Humans</term><term>Kinetics</term><term>Oligonucleotide Array Sequence Analysis</term><term>Polymerase Chain Reaction</term><term>Vero Cells</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Cellules Vero</term><term>Cinétique</term><term>Humains</term><term>Réaction de polymérisation en chaîne</term><term>Régulation de l'expression des gènes viraux</term><term>Séquençage par oligonucléotides en batterie</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The molecular basis of severe acute respiratory syndrome (SARS) coronavirus (CoV) induced pathology is still largely unclear. Many SARS patients suffer respiratory distress brought on by interstitial infiltration and frequently show peripheral blood lymphopenia and occasional leucopenia. One possible cause of this could be interstitial inflammation, following a localized host response. In this study, we therefore examine the immune response of SARS-CoV in human peripheral blood mononuclear cells (PBMCs) over the first 24 hours.</div></front></TEI><affiliations><list><country><li>Singapour</li></country></list><tree><noCountry><name sortKey="Chia, Jer Ming" sort="Chia, Jer Ming" uniqKey="Chia J" first="Jer-Ming" last="Chia">Jer-Ming Chia</name><name sortKey="Hibberd, Martin L" sort="Hibberd, Martin L" uniqKey="Hibberd M" first="Martin L" last="Hibberd">Martin L. Hibberd</name><name sortKey="Liu, Edison T" sort="Liu, Edison T" uniqKey="Liu E" first="Edison T" last="Liu">Edison T. Liu</name><name sortKey="Murthy, Karuturi R Krishna" sort="Murthy, Karuturi R Krishna" uniqKey="Murthy K" first="Karuturi R Krishna" last="Murthy">Karuturi R Krishna Murthy</name><name sortKey="Neo, Soek Ying" sort="Neo, Soek Ying" uniqKey="Neo S" first="Soek-Ying" last="Neo">Soek-Ying Neo</name><name sortKey="Ooi, Eng Eong" sort="Ooi, Eng Eong" uniqKey="Ooi E" first="Eng-Eong" last="Ooi">Eng-Eong Ooi</name><name sortKey="Ren, Ee Chee" sort="Ren, Ee Chee" uniqKey="Ren E" first="Ee-Chee" last="Ren">Ee-Chee Ren</name><name sortKey="Tan, Jenny" sort="Tan, Jenny" uniqKey="Tan J" first="Jenny" last="Tan">Jenny Tan</name><name sortKey="Tang, Kin Fai" sort="Tang, Kin Fai" uniqKey="Tang K" first="Kin-Fai" last="Tang">Kin-Fai Tang</name><name sortKey="Vega, Vinsensius B" sort="Vega, Vinsensius B" uniqKey="Vega V" first="Vinsensius B" last="Vega">Vinsensius B. Vega</name></noCountry><country name="Singapour"><noRegion><name sortKey="Ng, Lisa F P" sort="Ng, Lisa F P" uniqKey="Ng L" first="Lisa F P" last="Ng">Lisa F P. Ng</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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